ترجمه آماده – تاثیر کانول ها بر اثر پذیری متقابل پمپ قلب

Ventricular assist devices (VADs), which nowadays are mainly based on rotary blood pumps (RBPs), help to improve the blood circulation in patients with weakened ventricle [1-5]. They typically draw the blood from the left ventricular apex and pump it into the circulation through the inflow and outflow cannulas, respectively. While passing through the cannulas, the blood flow dissipates a remarkable portion of its energy received from the pump due to frictional and inertial losses. The frictional losses depend on the material, length, and diameter of the cannulas as well as the blood viscosity; the inertial losses are related to blood mass owing to pulsatility.
RBPs are typically characterized by their pressure head and flow rate curves or so-called the pump function graphs, which give information about what pressures and flow rates the pump can generate. Pump pressure head is usually defined as the difference in pressure between the inlet and outlet of the pump without the connecting cannulas. The cannulas are the primary interface between the device and the patient. In this study, we investigate the impact of cannulas on the pump pressure head. The main objective is to show how the cannulas affect the pump performance. We implanted the CentriMagTM RBP in three sheep via left thoracotomy and cannulated from ventricular apex to descending aorta. We examined pressure head and flow rate relationship of the pump including and excluding the cannulas at different continuous and pulsatile pump speeds.